In theory, it is possible to create humans without pain perception through genetic modification, but this has many complex and serious ethical and practical problems, and it is not allowed. Pain is an important protective mechanism of the human body. It allows us to perceive the damage to the body and respond in a timely manner to avoid further injury. If pain perception is eliminated, people may unknowingly suffer serious physical injury without knowing it, which can cause great harm to their health. At the same time, this approach seriously violates ethical principles. The natural physiological characteristics and diversity of human beings are precious. Changing basic perceptual functions at will destroys the integrity and dignity of human beings, and may cause a series of unpredictable social, ethical, and philosophical dilemmas. In modern medicine and scientific research, there are strict ethical norms that restrict the transformation of human genes that may bring huge risks and adverse consequences to ensure the healthy, fair and sustainable development of human society.